Mother of Perpetual Help Center, in Nong Bua Lamphu, Thailand, first opened in 1997 and became a Centre for persons with aids to come for counselling.  It later developed an orphanage of children born with HIV/AIDS and whose parents have died. Closest family members have to give them up due to poverty. As the orphans grow into young teenagers a new house has to be built. Ban Mae Marie (the House of Mary) now houses teenagers .

Mother of Perpetual Help Center also helps many young poor children who live in the vicinity. The Divine Word Missionaries believe that education is a good building block for life. They work with the Missionary Sisters of Charity of Mother Teresa who take care of the younger orphans.